Endocrine Abstracts

Background and Aim: Thyroid hormone beta receptor (TRβ) agonists have shown promising results to improve non-alcoholic steatohepatitis in preclinical studies and clinical trials. However, a recent cross-sectional study on human liver biopsies found that TRβ expression decreases during non-alcoholic steatohepatitis (NASH), which may indicate developing thyroid hormone resistance and pose a challenge for TRβ agonists. We aim to study how the changes in TRβ ex...

Objectives: Thyroid hormones (TH) affect cardiovascular functions via direct actions on the heart and via indirect actions on central nervous system. Mutations in TH receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart.Methods: The current experiments aimed at investigating the role of peripheral and central TR&...

Background and Aim: Hepatic thyroid hormone (TH) signalling plays an important role in onset and progression of liver diseases. Patients with altered thyroid hormone regulation in the liver, leading to a local hypothyroid, are at higher risk of developing non-alcoholic fatty liver disease (NAFLD). Treatment with thyroid hormones proved to be a promising therapy for these patients, slowing the progression of NAFLD to non-alcoholic steatohepatitis (NASH), a more advanced stage o...

Background and Aim: Altered hepatic thyroid hormone (TH) signalling is associated with the onset and progression of liver diseases. Local hepatic hypothyroidism is related to a higher incidence of developing non-alcoholic fatty liver disease (NASH) in humans and animal models. Thyroid hormone treatment proved to be a promising therapy, slowing the progression of NAFLD to non-alcoholic steatohepatitis (NASH), a more advanced stage of the disease characterized by inflammation an...